Nifedipine for anal fissures

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AIM : To investigate the efficacy of topical application of 0. The patients were encouraged to follow a high-fiber diet and assessed at 2, 4 and 8 wk post-treatment. The healing of fissure and any side effects were recorded.

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Nifedipine and diltiazem are calcium channel blockers. They are usually taken as pills to lower blood pressure. But these medicines can also help heal anal fissures.

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An anal fissure is a break or tear in the skin of the anal canal. Anal fissures may be noticed by bright red anal bleeding on toilet paper and undergarments, or sometimes in the toilet. If acute they are painful after defecation, [1] but with chronic fissures, pain intensity often reduces.

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No laboratory tests are indicated at this time. A majority of anal fissures heal on their own, and no treatment is needed. If treatment is necessary, the goal is to relieve pain and constipation.

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An anal fissure is a tear or ulcer in the lining of the anal canal, immediately within the anal margin. Clinical features of anal fissure include bleeding and persistent pain on defecation, and a linear split in the anal mucosa. Initial management of acute anal fissures present for less than 6 weeks should focus on ensuring that stools are soft and easily passed.

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Chronic anal fissure is the most common cause of anal pain associated with internal anal sphincter hypertonia. Reduction of hypertonocity is a special treatment for fissure healing. For this purpose chronic anal fissures were conventionally treated by anal dilatation or by lateral sphincterotomy.

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Clinical Question: Is a topical gel containing nifedipine and lidocaine effective in the treatment of chronic anal fissures? Synopsis: Treatment of chronic anal fissures includes stool softeners, topical anesthetics, and nitroglycerin ointment. Many patients are unable to tolerate the adverse affects e.


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